Route 16, or Highway 16, can refer to:
International
AH16 Asian Highway 16
E16 European route E16
E016 European route E016
Australia
– Thompsons Road (Victoria)
– South Australia
Canada
- Parts of the Trans-Canada Highway
- Yellowhead Highway, part of the Trans-Canada Highway system
Alberta Highway 16
Alberta Highway 16A
Alberta Highway 16X (former)
British Columbia Highway 16
Manitoba Highway 16
Manitoba Highway 16A
Saskatchewan Highway 16
Saskatchewan Highway 16A
Saskatchewan Highway 16B
New Brunswick Route 16
- Other instances of Highway 16
Nova Scotia Trunk 16
Ontario Highway 16
Prince Edward Island Route 16
China[
G16 Expressway
Czech Republic
I/16 Highway; Czech: Silnice I/16
India
National Highway 16 (India)
Israel
Highway 16 (Israel)
Iran
Road 16
Ireland
N16 road (Ireland)
Italy
Autostrada A16
RA 16
Japan
Japan National Route 16
Route 16 (Nagoya Expressway)
Ōsakakō Route
Korea, South
Ulsan Expressway
New Zealand
New Zealand State Highway 16
Paraguay
National Route 16
United Kingdom
British A16 (Peterborough-Grimsby)
United States
Interstate 16
U.S. Route 16
New England Route 16 (former)
Alabama State Route 16 (former)
Arkansas Highway 16
California State Route 16
County Route A16 (California)
County Route E16 (California)
County Route G16 (California)
County Route J16 (California)
County Route S16 (California)
Colorado State Highway 16
Connecticut Route 16
Delaware Route 16
Florida State Road 16
Georgia State Route 16
Hawaii Route 16 (former)
Idaho State Highway 16
Illinois Route 16
Indiana State Road 16
Iowa Highway 16
K-16 (Kansas highway)
Kentucky Route 16
Louisiana Highway 16
Louisiana State Route 16 (former)
Maine State Route 16
Maryland Route 16- Massachusetts Route 16
M-16 (Michigan highway) (former)
Minnesota State Highway 16
County Road 16 (St. Louis County, Minnesota)
- Mississippi Highway 16
Missouri Route 16
Montana Highway 16
Nebraska Highway 16
Nebraska Spur 16B
Nebraska Spur 16F
Nebraska Recreation Road 16C
Nebraska Recreation Road 16D
Nevada State Route 16 (former)
New Hampshire Route 16
New Hampshire Route 16B
New Mexico State Road 16
County Route 16 (Monmouth County, New Jersey)
New York State Route 16
County Route 16 (Allegany County, New York)- County Route 16 (Cattaraugus County, New York)
- County Route 16 (Cayuga County, New York)
- County Route 16 (Chautauqua County, New York)
- County Route 16 (Chenango County, New York)
County Route 16 (Clinton County, New York)
County Route 16 (Dutchess County, New York)
County Route 16 (Franklin County, New York)- County Route 16 (Herkimer County, New York)
- County Route 16 (Lewis County, New York)
- County Route 16 (Monroe County, New York)
- County Route 16 (Oneida County, New York)
County Route 16 (Orange County, New York)- County Route 16 (Otsego County, New York)
County Route 16 (Putnam County, New York)
County Route 16 (Rensselaer County, New York)- County Route 16 (Schenectady County, New York)
County Route 16 (Schuyler County, New York)- County Route 16 (Steuben County, New York)
County Route 16 (Suffolk County, New York)- County Route 16 (Ulster County, New York)
County Route 16 (Warren County, New York)
North Carolina Highway 16
North Dakota Highway 16
Ohio State Route 16
Oklahoma State Highway 16
Pennsylvania Route 16
South Carolina Highway 16
South Dakota Highway 16 (former)
South Dakota Highway 16B (former)
Tennessee State Route 16
Texas State Highway 16
Texas State Highway Loop 16 (former)
Texas State Highway Spur 16
Farm to Market Road 16
Texas Park Road 16
Utah State Route 16
Vermont Route 16
Virginia State Route 16
- State Route 16 (Virginia 1918-1940) (former)
Washington State Route 16
Primary State Highway 16 (Washington) (former)
West Virginia Route 16
Wisconsin Highway 16
- Territories
Guam Highway 16
Puerto Rico Highway 16